A commentary on modelling osteoarthritis pain in small animals.
نویسندگان
چکیده
OBJECTIVE To describe the currently used animal models for the study of osteoarthritis (OA) pain, with an emphasis on small animals (predominantly mice and rats). OUTLINE Narrative review summarizing the opportunities and limitations of the most commonly used small animal models for the study of pain and pain pathways associated with OA, and discussing currently used methods for pain assessment. Involvement of neural degeneration in OA is briefly discussed. A list of considerations when studying pain-related behaviours and pathways in animal models of OA is proposed. CONCLUSIONS Animal models offer great potential to unravel the complex pathophysiology of OA pain, its molecular and temporal regulation. They constitute a critical pathway for developing and testing disease-specific symptom-modifying therapeutic interventions. However, a number of issues remain to be resolved in order to standardize pre-clinical OA pain research and to optimize translation to clinical trials and patient therapies.
منابع مشابه
Effectiveness Of Continuous Versus Pulsed Short-Wave Diathermy In The Management Of Knee Osteoarthritis: A Randomised Pilot Study
Background: Short-wave diathermy (SWD) is an electrotherapeutic modality used in the conservative treatment of knee osteoarthritis (KOA). Electromagnetic radiation delivered in continuous (cSWD) or pulse (pSWD) mode provides a deep heating effect on tissues. There is no consensus on outcomes of treatment with cSWD versus pSWD in KOA. The aim of this study was to compare the effects of cSWD ve...
متن کاملComparative Study of the Effect of Tai Chi and Isometric Exercises on the Severity of Pain and Balance in Patients with Knee Osteoarthritis
Background: Osteoarthritis is a chronic and debilitating disease that often occurs in elderly populations, causing pain and loss of balance. The aim of this study was to compare the effect of Tai Chi and isometric exercises on the pain and balance in patients with knee osteoarthritis. Methods: In this study, 24 male subjects with knee osteoarthritis were selec...
متن کاملThe effect of regular exercise program on the pain of the elderly in knee osteoarthritis
Background & Aims: Knee osteoarthritis is one of the most common causes of pain, loss of function and disability in the elderly. Exercise is one of the measures suggested to manage the pain caused by Knee osteoarthritis. The aim of this study was to determine the effectiveness of regular exercise program at home on reducing knee osteoarthritis pain in the elderly. Materials & Methods: In this ...
متن کاملEffect of Satureja Hortensis Powder Supplementation on Pain and TNF-α in Patients with Knee Osteoarthritis: A Double-blind Randomized Clinical Trial
Abstract Introduction: The most prevalent type of arthritis is osteoarthritis which is known with the degenerative knee disease. Limited pieces of evidence have indicated that satureja with special phenol compounds is effective in inflammation reduction and pain alleviation. The aim of this study was to investigate the effect of Satureja Hortensis powder supplement on pain improvement and seru...
متن کاملThe Effect of a Period of Kinesiotherapy and Reflexology on Pain Intensity and Range of Motion in Elderly Women With Knee Osteoarthritis
Objective: The aim of this study was to compare the effect of a period of therapeutic exercise and reflexology on pain intensity and range of motion in elderly women with knee osteoarthritis. Methods: 45 elderly women with osteoarthritis of the knee were purposefully selected and randomly divided into three groups of 15: therapeutic exercise, reflexology and control. The therapeutic exercise a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Osteoarthritis and cartilage
دوره 21 9 شماره
صفحات -
تاریخ انتشار 2013